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Title   소화기 암환자의 요중 ( Polyamine Urinary Polyamines in Patients with Gastrointestinal Malignancy )
Publicationinfo   1991 Jan; 023(01): 76-83.
Key_word   Urinary polyamine, Gastrointestinal malignancy, Non-specific tumor marker
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Abstract   Urinary polyamines were determined in 100 patients (male 67, female 33), admitted at the Korea Cancer Center Hospital, with previously untreated gastrointestinal malignancy, 44 patients (male 29, female 15) with non-malignant gastrointestinal disease and 103 healthy persons (male 77, female 26). The mean of urinary polyamines (pmol/g creatinine) in healthy persons was 27.9+7.2, with female having slightly higher level of urinary polyamine than male. In this study, the positive for elevation of polyamine in urine was determined to be the value of more than mean plus two standard deviations (>= 40.0 in male, >= 44.0 in female). A significant increase in polyamine levels in urine was found in 100 patients with cancer (52.9+33,0), compared with controls. Positive for urinary polyamine was found in 53.0%. in 100 cancer patients (male 53.7%, female 51.5%): 41.1% in stomach cancer, 76.5% in hepatocellular carcinoma, 60.0%. in colon cancer, 88.9% in periampullary cancer and 37.5% in esophageal cancer. In stomach cancer, the pasitive rate increased progressively with the increase in stage: 25.0% in stage I, 30.4% in stage II-III and 51.7% in stage IV. In hepatocellular carcinoma, there were no significant differences in urinary polyamine levels between patients with less than 10 cm-size liver mass (80.0%) and more than 10 cm-sized mass (71.4%). Five out of seven patients (71.4%,) with more than 500 ng/ml of a-FP were positive for urinary polyamine and eight out of nine patients (88.9%) with less than 200 ng/ml of a-FP were positive. In 44 non-malignant gastrointestinal disease, only three patients (6.8%) had mild degree of elevation of urinary polyamine: one of seven patients with peptic ulcer, one of eight patients with liver cirrhosis, and one of 15 patients with chronic hepatitis. The sensitivity and specificity of urinary polyamine for the diagnosis of gastrointestinal malignancy were 53.0% and 93.2%, respectively, with diagnosability being considered to be 94.6%. These result suggest that the measurement of urinary polyamine is not specific for a particular cancer, however, useful as a non-specific tumor marker for the detection of gastrointestinal malignancy.
저 자   김서운(Seo Woon Kim),홍원선(Weon Seon Hong),김봉석(Bong Seog Kim),이영현(Young Hyun Lee),조희준(Hee Jun Cho),김창민(Chang Min Kim),이진오(Jhin Oh Lee),강태웅(Taik Koo Yun),홍석일(Seok Il Hong)